madiАвтомобиль. Дорога. Инфраструктура. = Avtomobil'. Doroga. Infrastruktura.Avtomobil'. Doroga. Infrastruktura.2409-7217МАДИmadi-179Research ArticleФизическая культураPhysical cultureНЕЙРОФИЗИОЛОГИЧЕСКИЕ И НЕЙРОБИОЛОГИЧЕСКИЕ АСПЕКТЫ ПЕДАГОГИКИNEUROPHYSIOLOGICAL AND NEUROBIOLOGICAL ASPECTS OF PEDAGOGYНамакановБорис АлександровичNamakanovBoris A.

д-р биол. наук, проф.

Ph. D., professor

kfv@madi.ruЩербаковаВера ЛьвовнаShcherbakovaVera L.

канд. биол. наук, доц.

Ph. D., associate professor

kfv@madi.ruМАДИРоссияMADIRussian Federation20152309201503(5)1515Copyright © Намаканов Б.А., Щербакова В.Л., 20152015Намаканов Б.А., Щербакова В.Л.Namakanov B.A., Shcherbakova V.L.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.adi-madi.ru/madi/article/view/179

Статья посвящена нейрофизиологическим и нейробиологическим аспектам педагогики. Подробно разбираются механизмы восприятия информации на уровне структур головного мозга. Обсуждаемая тема особенно полезна при рассмотрении новых образовательных программ. Материалы, представленные в статье основаны и на эволюционной теории, предполагающей большой сходство процессов обучения животных и человека.

The article is devoted to neurophysiological and neurobiological aspects of training. The process of training is connected with structures of brain. Results of reseach is useful for creation of University’s programs. According to theory of evolution process of training for animals and human is common.

педагогиканейробиологиянейрофизиологиятехнологии обученияneurophysiologyneurobiologyeducationReferencesBaillargeon R., Scott R.M. False-belief understanding in infants // Trends in Cognitive Sciences. 1 March 2010. V. 14, Issue 3. P. 110‒118.Baillargeon R., Scott R.M. False-belief understanding in infants, Trends in Cognitive Sciences, 1 March 2010, vol. 14, Issue 3, рр. 110‒118.Büchel C., Morris J., Dolan R., Friston K. Brain Systems Mediating Aversive Conditioning: an Event-Related fMRI Study // Neuron. 1 May 1998. V. 20, Issue 5. P. 947‒957.Büchel C., Morris J., Dolan R., Friston K. Brain Systems Mediating Aversive Conditioning: an Event-Related fMRI Study, Neuron, 1 May 1998, vol. 20, Issue 5, рр. 947‒957.Rochat M.J., Serra E., Fadiga L., Gallese V. The Evolution of Social Cognition: Goal Familiarity Shapes Monkeys' Action Understanding // Current Biology. 12 February 2008. V. 18, Issue 3. P. 227‒232.Rochat M.J., Serra E., Fadiga L., Gallese V. The Evolution of Social Cognition: Goal Familiarity Shapes Monkeys' Action Understanding, Current Biology, 12 February 2008, vol. 18, Issue 3, рр. 227‒232.Buchen L. How brain training makes multitasking easier, рractice speeds up the part of the brain that lets us tackle many jobs at once. 15 July 2009. doi: 10.1038/news.2009.690.Buchen L. How brain training makes multitasking easier, рractice speeds up the part of the brain that lets us tackle many jobs at once, 15 July 2009, doi: 10.1038/news.2009.690Katsnelson A. No gain from brain training. 20 April 2010. doi: 10.1038/4641111a.Katsnelson A. No gain from brain training, 20 April 2010, doi: 10.1038/4641111aOwen A.M. Nature advance online publication. doi: 10.1038/nature09042 (20 April 2010).Owen A.M. Nature advance online publication, doi: 10.1038/nature09042 (20 April 2010).Smith G.E. Am. Geriatr. Soc. 2009. № 57. Р. 594‒603.Smith G.E. Am. Geriatr. Soc, 2009, no. 57, рр. 594–603.Papp K.V., Walsh S.J. & Snyder, P. J. Alzheimers Dement. 2009. № 5. Р. 50‒60.Papp K.V., Walsh S.J. & Snyder, P. J. Alzheimers Dement, 2009, no. 5, рр. 50–60.Lugert S., Basak O., Knuckles P., Haussler U., Fabel K., Götz M., Haas C.А., Kempermann G., Taylor V., Giachino C. Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging // Cell Stem Cell. 2010. № 6 (5). Р. 445. doi: 10.1016/j.stem.2010.03.017.Lugert S., Basak O., Knuckles P., Haussler U., Fabel K., Götz M., Haas C.А., Kempermann G., Taylor V., Giachino C. Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging, Cell Stem Cell, 2010, no. 6 (5), р. 445, doi: 10.1016/j.stem.2010.03.017.Max-Planck-Gesellschaft. New nerve cells even in old age: Researchers find different types of stem cells in the brains of mature and old mice. ScienceDaily. Retrieved January 1, 2002, from http://www.sciencedaily.com /releases/2010/05/100506121751.htmMax-Planck-Gesellschaft. New nerve cells even in old age: Researchers find different types of stem cells in the brains of mature and old mice, Science Daily, Retrieved January 1, 2002, from http://www.sciencedaily.com /releases/2010/05/100506121751.htmNew Nerve Cells - Even in Old Age: Researchers Find Different Types of Stem Cells in the Brains of Mature and Old Mice // Science Daily. 2010.New Nerve Cells - Even in Old Age: Researchers Find Different Types of Stem Cells in the Brains of Mature and Old Mice, Science Daily, 2010.Artavanis-Tsakonas S.; Rand M.D.; Lake R. Notch Signaling: Cell Fate Control and Signal Integration in Development (Review) // Science. 1999. № 284 (5415). Р. 770–776. doi: 10.1126/science.284.5415.770.Artavanis-Tsakonas S., Rand M.D., Lake R. Notch Signaling: Cell Fate Control and Signal Integration in Development (Review), Science, 1999, no. 284 (5415), рр. 770–776, doi: 10.1126/science.284.5415.770.Brou C., Logeat F., Gupta N., Bessia C., LeBail O., Doedens J.R., Cumano A., Roux P., Black R.A., Israël A. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE // Mol. Cell. 2000. № 5 (2). Р. 207–216. doi: 10.1016/S1097-2765(00)80417-7.Brou C., Logeat F., Gupta N., Bessia C., LeBail O., Doedens J.R., Cumano A., Roux P., Black R.A., Israël A. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE, Mol. Cell. 2000, no. 5 (2), рр. 207–216, doi: 10.1016/S1097-2765(00)80417-7.Oswald F., Täuber B., Dobner T., Bourteele S., Kostezka U., Adler G., Liptay S., Schmid R.M. p300 acts as a transcriptional coactivator for mammalian Notch-1 // Mol. Cell. Biol. 2001. № 21 (22). Р. 7761–7774. doi: 10.1128/MCB.21.22.7761-7774.2001.Oswald F., Täuber B., Dobner T., Bourteele S., Kostezka U., Adler G., Liptay S., Schmid R.M. p300 acts as a transcriptional coactivator for mammalian Notch-1, Mol. Cell. Biol, 2001, no. 21 (22), рр. 7761–7774, doi: 10.1128/MCB.21.22.7761-7774.2001.Gaiano N., Fishell G. The role of notch in promoting glial and neural stem cell fates // Annu. Rev. Neurosci. 2002. № 25. Р. 471–490. doi: 10.1146/annurev.neuro.25.030702.130823.Gaiano N., Fishell G. The role of notch in promoting glial and neural stem cell fates, Annu. Rev. Neurosci, 2002, no. 25, рр. 471–490, doi: 10.1146/annurev.neuro.25.030702.130823.Bolós V., Grego-Bessa J., de la Pompa J.L. Notch signaling in development and cancer // Endocr. Rev. 2007. 28 (3). Р. 339–363. doi: 10.1210/er.2006-0046.Bolós V., Grego-Bessa J., de la Pompa J.L. Notch signaling in development and cancer, Endocr. Rev, 2007, 28 (3), рр. 339–363, doi: 10.1210/er.2006-0046.Liu Z.J., Shirakawa T., Li Y., Soma A., Oka M., Dotto G.P., Fairman R.M., Velazquez O.C., Herlyn M. Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis // Mol. Cell. Biol. 2003. № 23 (1). Р. 14–25. doi: 10.1128/MCB.23.1.14-25.2003.Liu Z.J., Shirakawa T., Li Y., Soma A., Oka M., Dotto G.P., Fairman R.M., Velazquez O.C., Herlyn M. Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis, Mol. Cell. Biol, 2003, no. 23 (1), рр. 14–25, doi: 10.1128/MCB.23.1.14-25.2003.Grego-Bessa J., Luna-Zurita L., del Monte G., Bolós V., Melgar P., Arandilla A., Garratt A.N., Zang H., Mukouyama Y.S., Chen H., Shou W., Ballestar E., Esteller M., Rojas A., Pérez-Pomares J.M., de la Pompa J.L. Notch signaling is essential for ventricular chamber development // Dev. Cell. 2007. № 12 (3). Р. 415–429. doi: 10.1016/j.devcel.2006.12.011.Grego-Bessa J., Luna-Zurita L., del Monte G., Bolós V., Melgar P., Arandilla A., Garratt A.N., Zang H., Mukouyama Y.S., Chen H., Shou W., Ballestar E., Esteller M., Rojas A., Pérez-Pomares J.M., de la Pompa J.L. Notch signaling is essential for ventricular chamber development, Dev. Cell, 2007, no. 12 (3), рр. 415–429, doi: 10.1016/j.devcel.2006.12.011.Murtaugh L.C., Stanger B.Z., Kwan K.M., Melton D.A. Notch signaling controls multiple steps of pancreatic differentiation // Proc. Natl. Acad. Sci. U.S.A. 2003. № 100 (25). Рр. 14920–14925. doi: 10.1073/pnas.2436557100.Murtaugh L.C., Stanger B.Z., Kwan K.M., Melton D.A. Notch signaling controls multiple steps of pancreatic differentiation, Proc. Natl. Acad. Sci. U.S.A., 2003, no. 100 (25), рр. 14920–14925,doi: 10.1073/pnas.2436557100.Sander G.R., Powell B.C. Expression of notch receptors and ligands in the adult gut // J. Histochem. Cytochem. № 52 (4). Р. 509–516. http://www.jhc.org/cgi/content/full/52/4/509.Sander G.R., Powell B.C. Expression of notch receptors and ligands in the adult gut, J. Histochem. Cytochem, no. 52 (4), рр. 509–516, http://www.jhc.org/cgi/content/full/52/4/509.Nobta M., Tsukazaki T., Shibata Y., Xin C., Moriishi T., Sakano S., Shindo H., Yamaguchi A. Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling // Biol. Chem. 2005. № 280 (16). Рр. 15842–15848. doi: 10.1074/jbc.M412891200.Nobta M., Tsukazaki T., Shibata Y., Xin C., Moriishi T., Sakano S., Shindo H., Yamaguchi A. Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling, Biol. Chem, 2005, no. 280 (16), рр. 15842–15848, doi: 10.1074/jbc.M412891200.Laky K., Fowlkes B.J. Notch signaling in CD4 and CD8 T cell development // Curr Opin Immunol. 2008. № 20 (2). Р. 197‒202.Laky K., Fowlkes B.J. Notch signaling in CD4 and CD8 T cell development, Curr Opin Immunol, 2008, no. 20 (2), рр. 197–202.Dontu G., Jackson K.W., McNicholas E., Kawamura M.J., Abdallah W.M., Wicha M.S. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells // Breast Cancer Res. 2004. № 6 (6). Р. R605–615. doi: 10.1186/bcr920.Dontu G., Jackson K.W., McNicholas E., Kawamura M.J., Abdallah W.M., Wicha M.S. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells, Breast Cancer Res, 2004, no. 6 (6), рр. R605–615, doi: 10.1186/bcr920.Lai E.C. Notch signaling: control of cell communication and cell fate // Development. 2004. № 131 (5). Рр. 965–973. doi: 10.1242/dev.01074.Lai E.C. Notch signaling: control of cell communication and cell fate, Development, 2004, no. 131 (5), рр. 965–973, doi: 10.1242/dev.01074.Sharma V.M., Draheim K.M., Kelliher M.A. The Notch1/c-Myc pathway in T cell leukemia // Cell Cycle. 2007. № 6 (8). Р. 927–930. http://www.landesbioscience.com/journals/cc/abstract.php?id=4134.Sharma V.M., Draheim K.M., Kelliher M.A. The Notch1/c-Myc pathway in T cell leukemia, Cell Cycle, 2007, no. 6 (8), рр. 927–930, http://www.landesbioscience.com/journals/cc/abstract.php?id=4134Moellering R.E. Direct inhibition of the NOTCH transcription factor complex // Nature. № 464. 2009. Р. 182–188. doi: 10.1038/nature08543.Moellering R.E. Direct inhibition of the NOTCH transcription factor complex, Nature, no. 464, 2009, рр. 182–188, doi: 10.1038/nature08543.Arora P.S., Ansari A.Z. Chemical biology: A Notch above other inhibitors // Nature. № 464. 2009. Р. 171–173. doi: 10.1038/462171a.Arora P.S., Ansari A.Z. Chemical biology: A Notch above other inhibitors, Nature, no. 464, 2009, рр. 171–173, doi: 10.1038/462171a.Bagley K. (2009-11-11). New drug target for cancer // The Scientist. http://www.the-scientist.com/blog/display/56143/.Bagley K. (2009-11-11). New drug target for cancer, The Scientist, http://www.the-scientist.com/blog/display/56143/Munro S., Freeman M. The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD// Curr. Biol. 2000. № 10 (14). Р. 813–20. doi: 10.1016/S0960-9822(00)00578-9.Munro S., Freeman M. The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD, Curr. Biol, 2000, no. 10 (14), рр. 813–20, doi: 10.1016/S0960-9822(00)00578-9.Ma B., Simala-Grant J.L., Taylor D.E. Fucosylation in prokaryotes and eukaryotes // Glycobiology. 2006. № 16 (12). Р. 158R–184R. doi: 10.1093/glycob/cwl040.Ma B., Simala-Grant J.L., Taylor D.E. Fucosylation in prokaryotes and eukaryotes, Glycobiology, 2006, no. 16 (12), рр. 158R–184R, doi:10.1093/glycob/cwl040.Shao L., Luo Y., Moloney D.J., Haltiwanger R. O-glycosylation of EGF repeats: identification and initial characterization of a UDP-glucose: protein O-glucosyltransferase // Glycobiology. 2002. № 12 (11). Р. 763–770. doi:10.1093/glycob/cwf085.Shao L., Luo Y., Moloney D.J., Haltiwanger R. O-glycosylation of EGF repeats: identification and initial characterization of a UDP-glucose: protein O-glucosyltransferase, Glycobiology, 2002, no. 12 (11), рр. 763–770, doi:10.1093/glycob/cwf085.

The authors declare that there are no conflicts of interest present.